Screening for Cross-Reactivity and Validation of Peptide-Centric CAR-T Cells for Neuroblastoma using MHC Dextramer®
Maximize the Potential of Cell Therapy
Explore how Dextramer® reagents support the development and manufacturing of effective cellular immunotherapies.
Monitor Antigen Specificity
Specificity can be key to successful immune cell therapy. Immudex provides high-quality Dextramer® reagents that enable precision cellular immune monitoring of antigen-specific cells for advanced cell therapy.
Reagents for Development and Manufacturing
Immudex is committed to providing sensitive Dextramer® reagents for precise detection, isolation, and validation of antigen-specific cells in cell therapy development and manufacturing.
Clinical Grade Reagents
Immudex provides high-quality GMP Dextramer® reagents that meet authoritative standards for production and manufacturing of cell therapy products.
Webinar: Discover and Validate TCR Candidates with Dextramer® Technology
Finding the right TCR for immunotherapy can be like looking for a needle in a haystack. In this webinar, our Senior Research Scientist and TCR expert Thomas Holberg Blicher guides you through the latest techniques and tools for identifying candidate TCRs and how those TCRs can be used to investigate binding and target expression in cells.
TCR-T Cell Therapy
Explore the wide range of cellular immunotherapies, including approved therapies, and learn more about TCR-based immunotherapies and the diseases to which they are applied. We highlight why a thorough understanding of the antigen-specific interaction is critical for the development of effective TCR-T therapeutics, and explain how Immudex’s products including Dextramer® technology and TCR Solutions can support the development and manufacturing of these therapies.
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Specificity can be Key to Successful Immune Cell Therapy
Immudex provides high-quality Dextramer® reagents that enable precision cellular immune monitoring of antigen-specific cells.
Dextramer® technology can characterize and validate antigen-specific cell therapy products with high resolution during development, manufacturing, and release testing.
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Develop and Manufacture TCR-T Cell Therapies with Dextramer® Technology
- Epitope and neoepitope discovery
- TCR discovery, characterization, and validation including screening for TCR specificity and cross-reactivity
- Characterization and monitoring of antigen-specific cell therapy products in preclinical and clinical research
- Clinical-Grade (GMP) Dextramer® reagents for in-process control and release testing during manufacturing of cell therapy products
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CAR-T Therapy
Klickmer® technology enables the creation of customized multimers that bind with high avidity to your target of choice. This technology may help to directly detect and quantify CAR-T cells with high sensitivity. Barcode enabled dCODE Klickmer® reagents allow in-depth characterization of CAR-T cells.
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Explore Case Studies – Applications of Dextramer® Technology in Cell Therapy
Assessing the HLA-Specificity of CAR-T Cells with MHC I Dextramer® Reagents
Plasmacytoid Dendritic Cell Line-Based Vaccine Primes and Expands Antitumor T Cells in Melanoma Patients
A TCR-Accepting T-Cell Platform to Profile Tumor-Specific T-Cell Receptors
Identifying Shared Tumor Epitopes from Endogenous Retroviruses for High-Avidity Cytotoxic TILs using MHC Dextramer®
Cancer Neoepitopes for Immunotherapy: Strategies for Adoptive T-Cell Therapy
Identification of Epitopes that Pose as Attractive Targets for Vaccination and Other T-Cell Therapies with Klickmer®
Assessment of the safety and efficacy of a novel vaccine in high-grade glioma patients with Dextramer®
Exploring Neoantigen Cancer Vaccines in Combination with Immune Checkpoint Inhibitors Using MHC Dextramer®
Dextramer® Reagents Enable TCR Discovery
Immudex provides a range of ready-to-use, customizable, and peptide-receptive Dextramer® reagents enabling the discovery, characterization, and isolation of TCRs with therapeutic value across different platforms, including in-situ, flow cytometry, NGS, and single-cell multi‑omics.
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TCR Solutions
Immudex offers TCR Solutions providing Soluble TCR Monomers and TCR Dextramer® reagents to enable the quantification of Antigen-Presenting Cells, validation of TCR candidates, and other applications within CAR-T and TCR-T therapy.
Discover TCR Solutions
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