Monitor Cellular Immunity in Infectious Diseases

Define factors of protective immunity and identify effective vaccine antigens

Solutions for Your Research Needs

Every day, immunologists make new discoveries that deepen our understanding of how the immune system responds to infectious diseases.. Learn how Dextramer® technology can help you detect, quantify, or isolate pathogen-specific CD8+ and CD4+ T cells in peripheral blood, cell cultures, or tissue across different platforms, allowing you to continue directly from in-situ, to flow cytometry, and move onto NGS or single-cell multi-omics:

• MHC I and MHC II Dextramer® reagents comprise a broad selection of T-cell epitopes to monitor the whole spectrum of virus- or bacterial-specific T-cell responses by flow cytometry, including T cells with rare and low-affinity receptors.
• MHC I Dextramer® In-Situ Staining reagents can help detect distinct localization, distribution, and abundance of virus- or bacterial-specific CD8+ T cells within diverse tissue niches in health and disease.
• dCODE Dextramer® reagents for epitope discovery and T-cell profiling in bulk solution or at single-cell level. The unique DNA barcode enables the detection of antigen-specific T cells by PCR followed by next generation sequencing (NGS) and single-cell multi-omics.
• U-Load Dextramer® reagents to easily make your choice of customized multimers directly in the lab from a broad range of peptide-receptive MHC I and MHC II alleles and your own peptide, via flow cytometry or single-cell multi-omics.
• Klickmer® reagents can be customized to help you to explore immunity beyond T cells by looking into other immune cells like B cells or study TCR-ligand interactions in virus cells by flow cytometry or single-cell multi-omics.

Published Viral T-Cell Epitopes

To support clinicians and scientists worldwide in their virus research, we want to share curated lists of the human, mouse, and primate viral antigens recognized by CD8+ and CD4+ T cells. These lists of virus-specific T-cell epitopes reflect the product portfolio of Immudex and the research of many dedicated scientists published in peer-reviewed papers. You can now select the epitopes from the comprehensive lists that best fit your research within infectious disease or vaccine development.

Dextramer® Panels

Our predefined products and Panels of Dextramer® reagents address highly relevant viral or bacterial infections. Alternatively, you can select antigens of interest from our epitope lists, product menu – or define custom Dextramer® reagents

Virus Dextramer® Panel

Measure immune status with selected Dextramer® reagents displaying epitopes of the opportunistic cytomegalovirus, Epstein-Barr virus, influenza, and BK virus.
Opportunistic viruses can cause severe diseases in immune-compromised patients. Measuring the virus immune status is an important tool to check the risk of infection in immune-compromised patients.

Order MHC Dextramer® Virus Panel

COVID-19 Dextramer® Panels

A deeper understanding of COVID-19 immunity is needed to explore vaccine responses, long-term immunity, predict patients at risk, and even prepare ourselves for a possible new pandemic in the future.
Our unique immune monitoring tools can help you unravel the SARS-CoV-2 specific T-cell immunity in an easy and reproducible way.

We provide SARS-CoV-2 Dextramer® reagents in panels targeting Spike or Non-Spike epitopes, each with a selection of validated T-cell epitopes.

Alternatively, select your own custom panel based on our selection of SARS-CoV-2 Dextramer® reagents, or order individual Dextramer® reagents.

Learn more about our SARS-CoV-2 Dextramer® reagents and panels here.

CMV Dextramer® Panel

CMV infection and disease pose a major risk in immunosuppressed patients. Reactivation of CMV is a frequently occurring complication and can contribute to morbidity and mortality if not controlled. CMV-specific CD8+ T cells are considered the main factor in successful management of CMV infection. In transplant patients, a low number of CMV-specific CD8+ T cells are predictive for development of CMV-related complications.​

Support successful management of cytomegalovirus infection in transplant patients with well-characterized, virus-specific epitopes.

Order MHC Dextramer® CMV Panel

EBV Dextramer® Panel

EBV is a persistent virus that infects 90% of the human population. Primary infection may cause acute infectious mononucleosis, and persistent infection may be associated with the development of several malignancies. T cells play a critical role in controlling both the primary and persistent phases of infection.

Detect, quantify, and isolate EBV-specific T cells and obtain information about the patients’ virus immune status.

Order MHC Dextramer® EBV Panel

Bacterial and Parasitic Disease Dextramer® Products​

T cells are one of the cornerstones of the immunological response against infections caused by bacterial pathogens and parasitic organisms. Detection and monitoring of antigen-specific T cells is of great importance in studies of immune protection. Our immune monitoring tools can help you to investigate the T-cell response in diseases ranging from Tuberculosis (Mycobacterium tuberculosis) to Malaria (Plasmodium), Enterococcus faecium, and Lyme borreliosis (Borrelia burgdorferi).​

Order Bacterial and Parasitic Disease Dextramer® Products​

Accelerate Your Vaccine Development Research

See how dCODE Dextramer® technologies can advance all vaccine development phases, from selecting candidate viral epitopes to monitoring vaccine efficacy by measuring antigen-specific immunity.

Read More

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