High throughput characterization of neoantigen specific T cells and cognate T cell receptors for the treatment of leukemia
Webinar Recording
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This webinar covers:
- Uncovering how mutations in RNA splicing factors - frequently found in certain cancers - generate shared mis-splicing-derived neoantigens across patients
- Leveraging DNA barcoded MHC Dextramer® and single cell analysis to characterize neoantigen-specific T cells in patient blood samples and discover TCRs targeting common neoantigens
Short summary:
Identification and characterization of antigen-specific T cells is critical to understanding immune response to cancer and developing antigen-specific therapies such as T cell receptor (TCR) derived therapies and cancer vaccines. This presentation will describe the use of feature-barcoded peptide-MHC Dextramer® to characterize neoantigen specific T cells in patients with cancer and isolate neoantigen-reactive TCRs.
Speakers:
- Omar Abdel-Wahab, MD-Memorial Sloan Kettering Cancer Center
- Niels Montano Frandsen, PhD - Immudex